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| Amorim,Rodrigo das Neves dos Santos; Rodrigues,José Ariévilo Gurgel; Holanda,Márjory Lima; Quinderé,Ana Luíza Gomes; Paula,Regina Célia Monteiro de; Melo,Vânia Maria Maciel; Benevides,Norma Maria Barros. |
| The aim of this study was to determine the yield, chemical composition, specific rotation (SR), infrared (IR) spectroscopy and the effect on bacterial growth of a crude sulfated polysaccharide (SP) from the red marine alga G. ornata (Go). Go-1 (25°C), Go-2 (80°C), and Go-3 (80°C) were sequentially extracted and yielded 9.2%. The contents of sulfate (5.88-10.3%) and proteins (0.1-3.7%) were small. The values of SR were [µ]D20°f -19.0, -51.0, and -56.5, respectively. IR spectrums showed the presence of galactose-4 sulfate and absence of 3,6-anydrogalactose-2 sulfate, galactose-6 sulfate and galactose-2 sulfate. SR and IR techniques confirmed SPs. Go-3 was tested on the growth of bacteria (Bacillus subtilis, Staphylococcus aureus, Enterobacter aerogens,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rhodophyta; Sulfated macromolecules; Chemical analysis; Antimicrobial. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200001 |
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| Cordeiro,Rossana Aguiar; Gomes,Valdirene Moreira; Carvalho,Ana Fontenele Urano; Melo,Vânia Maria Maciel. |
| A protein fraction, rich in lectin, obtained from the red seaweed Hypnea musciformis by precipitation with ammonium sulfate (F40/70) was screened for chitinase and beta-1,3-glucanase activity and assessed for antifungal potential against the human pathogen yeasts Candida albicans and C. guilliermondii. The F40/70 fraction showed chitinase and beta-1,3-glucanase enzymes, with specific activities of 276.43 and 1880.7 Units.mg -1 protein, respectively. It was capable of inhibiting the growth of C. guilliermondii at the concentrations of 45, 100 and 450 µg protein.ml -1 but it showed only a discrete inhibition against C. albicans irrespective of the tested concentrations. The inhibitory action was shown to be fungistatic and the presence of the glycoprotein... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypnea musciformis antifungal activity beta-1; 3-glucanase chitinase lectin. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000700008 |
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| Lopes,José Luiz de Souza; Hissa,Denise Cavalcante; Melo,Vânia Maria Maciel; Beltramini,Leila Maria. |
| The amidated analog of Plantaricin149, an antimicrobial peptide from Lactobacillus plantarum NRIC 149, directly interacts with negatively charged liposomes and bacterial membranes, leading to their lysis. In this study, four Pln149-analogs were synthesized with different hydrophobic groups at their N-terminus with the goal of evaluating the effect of the modifications at this region in the peptide's antimicrobial properties. The interaction of these peptides with membrane models, surface activity, their hemolytic effect on red blood cells, and antibacterial activity against microorganisms were evaluated. The analogs presented similar action of Plantaricin149a; three of them with no hemolytic effect (< 5%) until 0.5 mM, in addition to the induction of a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity antimicrobial peptide calcein leakage; Hemolytic assay. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000400038 |
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